Pharmacokinetics Scroll Story
Wonderful Wednesdays • 2026-06-10 challenge
Why this story
A single oral dose, 50 subjects, plasma concentration followed for 24 hours. Scroll through four questions, one full screen at a time:
- What is the population-level PK pattern over time?
- How much between-subject variability is present at each time point?
- How consistent are peak timing (Tmax) and peak concentration (Cmax) across subjects?
- Is the overall profile shape consistent after normalizing by subject peak?
Dataset scope: 50 subjects, 8 post-dose time points (0.5, 1, 2, 4, 6, 8, 12, 24 h) up to 24 hours.
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At a glance
Population-level PK metrics (per-subject values summarized as median [IQR]):
| Metric | Value |
|---|---|
| Subjects × time points | 50 × 8 (single oral dose, 0–24 h) |
| Median Cmax | 79.5 ng/mL [75.2–82.3] |
| Median Tmax | 2.0 h (86% of subjects peak at 2 h) |
| Median AUC(0.5–24 h) | 913 ng·h/mL [823–1084] |
| Apparent terminal t½ (from ≥8 h) | 6.9 h (n = 50) |
AUC is trapezoidal over the observed sampling window (first sample at 0.5 h, so this is not extrapolated to time 0 or infinity). Half-life is an apparent terminal estimate from the log-linear tail and is provided as an orientation value only.
Individual trajectories
Hover any line to highlight that subject and read their ID and values — all other lines fade out. The visual noise is the message: 50 subjects, all different.
Population fan — linear axis
The same variability distilled into a clean quantile fan. The fan width at each time is the key signal. On the linear axis the rise-to-peak reads directly.
Population fan — log axis
The same fan on a log y-axis. Concentrations span ~31× across the window, so the post-peak decline straightens into the near-linear elimination phase.
Variability by time point
Spread and skew at each sampling time. The box shows the IQR; every jittered point is one subject.
Peak behavior — Cmax & Tmax
Peak timing is remarkably consistent: 86% of subjects peak at 2 h, with the remainder at 4 h. Because Tmax takes only a couple of discrete values here, a Cmax-vs-Tmax scatter with a trend line would be misleading — so we show the Cmax distribution grouped by Tmax, every subject a jittered point. Do the late-peaking subjects reach different concentrations?
Normalized profile shape
Normalizing each profile by its subject-level peak (C/Cmax) highlights shape differences independent of magnitude. Hover over any data point to see the subject.
Takeaways
- The median PK curve rises to a peak at 2.0 h (~79.1 ng/mL) and declines over 24 hours, with an apparent terminal half-life of ~6.9 h.
- Between-subject variability is visible at all time points, widest around the peak window; concentrations span ~31× across the study.
- Peak timing is highly consistent (86% peak at 2 h), and Cmax is relatively tight (median 79.5 ng/mL [75.2–82.3]).
- After normalization, profile shapes are broadly similar but still show meaningful heterogeneity, especially in the elimination phase.