Repository to hold the data and materials for the Wonderful Wednesdays webinar series https://www.psiweb.org/sigs-special-interest-groups/visualisation/welcome-to-wonderful-wednesdays
Background: The assessment of benefit-risk profiles is crucial in drug development and regulatory decision-making. Effective visualization of these profiles can greatly enhance understanding and communication among stakeholders. This challenge is inspired by the work presented in the paper: “Planning Benefit-Risk Assessments Using Visualizations” by Colopy MW, Gakava L, Chen C. Ther Innov Regul Sci. 2023 Nov;57(6):1123-1135. doi: 10.1007/s43441-023-00563-9. Epub 2023 Sep 8. PMID: 37682462.
In their paper, Colopy et al. emphasize the importance of proactive planning in benefit-risk assessments and propose various visualization techniques to facilitate this process. They present a series of visualizations that progress from analyzing the medical condition and current treatment options to assessing the investigational drug.
Data set: For this challenge, you will be working with a dataset (brdata.xlsx). The Excel spreadsheet contains two tabs:
“brdata”: This tab provides the primary data for your visualization. It includes information on various clinical outcomes, quality of life measures, and drug characteristics for multiple treatments compared to placebo. You will use this data to create your visualizations.
“description”: Refer to this tab for detailed descriptions of all variables found in the “brdata” tab.
The Challenge: Create a visualization (or set of visualizations) using the provided dataset to effectively communicate the benefit-risk profiles of the drugs. Your visualization should aim to address one or more of the following aspects:
Comparative efficacy and safety of the drugs against placebo
Gender-specific effects of treatments
Differences between approved and test drugs
Relationships between different outcomes (e.g., clinical assessments and quality of life)
Uncertainty or variability in the data
There are no strict restrictions on the type of visualization or the specific questions you choose to address. Your goal is to create a visualization that provides meaningful insights into the benefit-risk profiles and facilitates decision-making in drug development.
Submission Requirements:
Your visualization(s) in a high-resolution format
Reproducible code used to create the visualization(s)
Reference: Colopy MW, Gakava L, Chen C. Planning Benefit-Risk Assessments Using Visualizations. Ther Innov Regul Sci. 2023 Nov;57(6):1123-1135. doi: 10.1007/s43441-023-00563-9. Epub 2023 Sep 8. PMID: 37682462.